Water → 4-(4-Phenyl-2-pyrimidinyl)butanal

HRID 19663노트

반응식

HRID 19663 반응식
[CH2:1]([C:6]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:9]=[CH:8][N:7]=1)[CH2:2][CH2:3][CH:4]=C.[OH2:18]>C1COCC1.O.O=[Os](=O)(=O)=O>[C:12]1([C:10]2[CH:9]=[CH:8][N:7]=[C:6]([CH2:1][CH2:2][CH2:3][CH:4]=[O:18])[N:11]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 578564872-(4-Penten-1-yl)-4-phenylpyrimidine

생성물 1

HCID 578564634-(4-Phenyl-2-pyrimidinyl)butanal

시약·촉매·용매 2

HCID 30318Osmium Tetroxide촉매HCID 21881883Oxolane--water (1/1)용매

실험 절차

To a stirred solution of 2-(4-penten-1-yl)-4-phenylpyrimidine (P5, 142 mg) in THF/H2O (5/1 mL) were added OsO4 (4% in water, 0.2 mL) and NaIO4 (404 mg). The solution was stirred at room temperature for 0.5 h. Water was then added and the mixture extracted with DCM. The organic phase was washed with brine, dried over Na2SO4, filtered and evaporated in vacuo to give 141 mg of the title compound as an oil, which was used in the subsequent step without further purification.

후처리

  1. extractionthe mixture extracted with DCM
  2. washThe organic phase was washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-23699602754a4235bc24b972126b8826
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745458B2

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