Nitric Acid → 4-Bromo-2-fluoro-5-nitrobenzaldehyde

HRID 1966311노트

반응식

HRID 1966311 반응식
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[C:8]([F:14])[CH:7]=1>S(=O)(=O)(O)O>[Br:5][C:6]1[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:9]([CH:10]=[O:11])=[C:8]([F:14])[CH:7]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 1435174-Bromo-2-fluorobenzaldehyde

생성물 1

HCID 184555954-Bromo-2-fluoro-5-nitrobenzaldehyde

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Nitric acid (25 mL) is added dropwise to a solution of 4-bromo-2-fluorobenzaldehyde (5.12 g, 25.2 mmol) in sulfuric acid (25 mL). The mixture is stirred for 2 hours and then is poured over ice. Product is extracted into MTBE (100 mL). The organic layer is washed with saturated aqueous NaHCO3 (100 mL), dried (Na2SO4), and evaporated yielding 5.98 g of yellow solid. 1H NMR (DMSO-d6) δ 10.13, 8.49, 8.22.

후처리

  1. additionis poured over ice
  2. extractionProduct is extracted into MTBE (100 mL)
  3. washThe organic layer is washed with saturated aqueous NaHCO3 (100 mL)
  4. dry with materialdried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-80c90b47904e42f0a92f4d2eb3cfc562
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420646B2

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