Piperazine → HCID 18423149, 화합물

HRID 1966342노트

반응식

HRID 1966342 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([O:14][CH3:15])[N:11]=[C:10]([O:16][CH3:17])[CH:9]=1>C(#N)C>[CH3:15][O:14][C:12]1[N:11]=[C:10]([O:16][CH3:17])[CH:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[N:13]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 806004-Chloro-2,6-dimethoxypyrimidine

생성물 1

HCID 18423149HCID 18423149, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

후처리

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with aqueous sodium bicarbonate solution
  4. customevaporated

출처 및 근거

ORD 기록
ord-a895a98daf4a46cd8f09955978a65b18
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420653B2

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