Dimethylformamide → [(4-Chlorophenyl)-pyridin-4-ylmethyl]-(8-methoxy-2-methylquinolin-4-yl)-amine

HRID 1966538

반응식

HRID 1966538 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH2:29])[C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1.CN(C)C=O>C(#N)C>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH:29][C:2]2[C:11]3[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:14])[CH:3]=2)[C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8075834-Chloro-8-methoxy-2-methylquinolineHCID 3157463(4-Chlorophenyl)(pyridin-4-yl)methanamine

생성물 1

HCID 59474758[(4-Chlorophenyl)-pyridin-4-ylmethyl]-(8-methoxy-2-methylquinolin-4-yl)-amine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Preparation was made using a similar procedure as described in example 19, method 19.2. Starting materials were 4-chloro-8-methoxy-2-methylquinoline and C-(4-chlorophenyl)-C-pyridin-4-yl-methylamine. Acetonitrile was used as solvent instead of dimethylformamide.

후처리

  1. customPreparation

출처 및 근거

ORD 기록
ord-b7e2d59b8a3942b6964f53a320d70a02
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420670B2

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