6-(2,2-Difluoro-2-phenylethoxy)-1-hexanamine → {6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine

반응식

[F:1][C:2]([F:29])([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1C(=O)C2C(=CC=CC=2)C1=O.FC(F)(C1C=CC=CC=1)COCCCCCCN>>[F:1][C:2]([F:29])([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11]

참가 물질

반응물 2

HCID 509930806-(2,2-Difluoro-2-phenylethoxy)-1-hexanamine

HCID 672465922-{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 67247388{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine

실험 절차

Obtained from Intermediate 31 (4.0 g, 14.4 mmol) by the procedure described in Intermediate 9. {6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine was obtained (1.93 g, 50%) as oil.

출처 및 근거

ORD 기록: ord-c388be7790604d948ca87547ab8b4f21
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08420669B2

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