Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate → Ethyl (2E)-4,4,5,5-tetrafluoro-6-{[(2E)-3-phenylprop-2-en-1-yl]oxy}-hex-2-enoate
반응식
[F:1][C:2]([F:19])([C:5]([F:18])([F:17])[CH2:6][O:7][CH2:8]/[CH:9]=[CH:10]/[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH:3]=O.FC(F)(C1C=CC=CC=1)/C=[CH:23]/[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[F:1][C:2]([F:19])([C:5]([F:18])([F:17])[CH2:6][O:7][CH2:8]/[CH:9]=[CH:10]/[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)/[CH:3]=[CH:23]/[C:24]([O:26][CH2:27][CH3:28])=[O:25]참가 물질
3
실험 절차
Obtained from Intermediate 38 (1.37 g, 4.96 mmol) by the procedure described in Intermediate 20. Purification by column chromatography with silica gel using n-hexane/ethyl acetate (15:1) as eluent gave the title compound (1.2 g, 70%) as oil.
후처리
- customPurification by column chromatography with silica gel