2,2-Difluoro-4-phenylbutan-1-ol → 4,4,5,5-Tetrafluoro-6-(3-phenylpropoxy)hexan-1-ol

반응식

[F:1][C:2]([F:24])([C:10]([F:23])([F:22])[CH2:11][O:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:24])([C:10]([F:22])([F:23])[CH2:11][O:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:3][CH2:4][CH2:5][OH:6]

참가 물질

반응물 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

HCID 86658312Ethyl 4,4,5,5-tetrafluoro-6-(3-phenylpropoxy)hexanoate

생성물 1

HCID 866583114,4,5,5-Tetrafluoro-6-(3-phenylpropoxy)hexan-1-ol수율 82%

실험 절차

Obtained from Intermediate 40 (1.0 g, 2.85 mmol) by the procedure described in Intermediate 2. Purification by column chromatography with silica gel and n-hexane/ethyl acetate (from 10:1 to 5:1) as eluent gave the title compound (0.68 g, 82%) as oil.

후처리

customPurification by column chromatography with silica gel and n-hexane/ethyl acetate (from 10:1 to 5:1) as eluent

출처 및 근거

ORD 기록: ord-617411e14a584288a477dd57c4e966b6
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08420669B2

반응 노트

불러오는 중…