3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

HRID 1966658노트

반응식

HRID 1966658 반응식
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:8].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8]

참가 물질

3

반응물 2

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 866583073-(4-Phenylbutoxy)propionaldehyde

생성물 1

HCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanal수율 60.3%

실험 절차

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

후처리

  1. customPurification by column chromatography with silica gel eluting with methylene chloride

출처 및 근거

ORD 기록
ord-9e98ee0d72ee4f88bf2264d780f5ceeb
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420669B2

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