1-(4-Phenylbutoxy)hept-6-en-3-ol → 1-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-ol

HRID 1966659노트

반응식

HRID 1966659 반응식
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8].[C:16]1(CCCCOCCC(O)CCC=C)[CH:21]=CC=[CH:18][CH:17]=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]([OH:8])[CH2:18][CH2:17][CH:16]=[CH2:21]

참가 물질

3

반응물 2

HCID 672444321-(4-Phenylbutoxy)hept-6-en-3-olHCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanal

생성물 1

HCID 672453981-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-ol수율 53%

실험 절차

Obtained from Intermediate 82 (1.86 g, 8.7 mmol) by the procedure described in Intermediate 14. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:6) gave the title compound (1.24 g, 53%) as oil.

후처리

  1. customPurification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:6)

출처 및 근거

ORD 기록
ord-74748bd3a73b4801ac2509a0c26007e9
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420669B2

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