HCID 58542057, 화합물 → HCID 58541981, 화합물
반응식
[CH:1]([C:4]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][OH:16])[O:6][N:5]=1)([CH3:3])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH:1]([C:4]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH:15]=[O:16])[O:6][N:5]=1)([CH3:3])[CH3:2]참가 물질
4
실험 절차
To a solution of [2-(3-isopropyl-1,2,4-oxadiazol-5-yl)-phenyl]methanol (373 mg, 1.71 mmol) in CH2Cl2 (5.0 mL) is added MnO2 (300 mg, 3.45 mmol). The reaction mixture is stirred at room temperature for 48 hours and is filtered through diatomaceous earth. The filtrate is concentrated under reduced pressure and the residue is purified by silica gel flash column chromatography with 30% EtOAc in heptanes as the eluent to afford 2-(3-isopropyl-1,2,4-oxadiazol-5-yl)-benzaldehyde (139 mg, 37%).
후처리
- filtrationis filtered through diatomaceous earth
- concentrationThe filtrate is concentrated under reduced pressure
- customthe residue is purified by silica gel flash column chromatography with 30% EtOAc in heptanes as the eluent
출처 및 근거
- ORD 기록
- ord-8ea8591ca03743d2a4cd34f4d01204a7
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420655B2
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