Hydrogen Peroxide → HCID 58541889, 화합물

HRID 1966725노트

반응식

HRID 1966725 반응식
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:7]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[C:11]#[N:12])=[N:8][C:4]=2[CH:3]=1.[OH-:23].[NH4+].OO>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]([C:17]([CH3:18])([CH3:19])[CH3:20])[C:7]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[C:11]([NH2:12])=[O:23])=[N:8][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 14923Ammonium HydroxideHCID 58542011HCID 58542011, 화합물

생성물 1

HCID 58541889HCID 58541889, 화합물수율 84%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a round bottom flask is added 2-(5-bromo-1-tert-butyl-1H-benzimidazol-2-yl)-benzonitrile (1800 mg, 5.08 mmol) in MeOH (40 mL), followed by the addition of ammonium hydroxide (20 mL) and hydrogen peroxide (10 mL) (30% in water). The reaction mixture is stirred at room temperature for 3 hours. The reaction mixture is concentrated in vacuo. The residue is diluted with EtOAc, washed with water then brine, dried under Na2SO4, filtered and concentrated. The residue is loaded onto a silica gel column. The column is eluted with 0-4% MeOH/CH2Cl2. The product fractions are collected and concentrated to afford 2-(5-bromo-1-tert-butyl-1H-benzimidazol-2-yl)-benzamide (1590 mg, 84%) as a light brown solid. LCMS (ESMS): m/z 372.46, 374.35 (M++1)

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. additionThe residue is diluted with EtOAc
  3. washwashed with water
  4. dry with materialbrine, dried under Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. washThe column is eluted with 0-4% MeOH/CH2Cl2
  8. customThe product fractions are collected
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-70def71dad41472a8face902f5ba2d4a
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420655B2

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