Urea → 5-Fluoroisoindoline-1,3-dione
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.[NH2:13]C(N)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][CH:12]=1)[C:6](=[O:7])[NH:13][C:9]2=[O:8]참가 물질
4
실험 절차
To 4-fluorophthalic anhydride (5.0 g, 30.10 mmol) in toluene (15 mL) is added urea (2.1 g). The reaction mixture is stirred at refluxed for 16 h. The reaction mixture is allowed to cool to room temperature, concentrated under reduced pressure and triturated with H2O (250 mL) to afford 5-fluoro-isoindole-1,3-dione (5.0 g, 100%) as a white solid.
후처리
- temperatureat refluxed for 16 h
- concentrationconcentrated under reduced pressure
- customtriturated with H2O (250 mL)
출처 및 근거
- ORD 기록
- ord-4fbb8245889046fba2c7849229bb340b
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420655B2
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