Ethylacetate heptane → 4-(2,5-Dichloro-phenoxy)-N-methyl-N-(1,2,3,4-tetrahydro-quinolin-8-yl)-nicotinamide

HRID 1967000노트

반응식

HRID 1967000 반응식
[Cl:1][C:2]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:3]=1[O:4][C:5]1[C:10]([C:11]([NH:13][C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[NH:22][CH2:21][CH2:20][CH2:19]3)=[O:12])=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:29]CCCCCC.C(OCC)(=O)C>>[Cl:1][C:2]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:3]=1[O:4][C:5]1[C:10]([C:11]([N:13]([CH3:29])[C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[NH:22][CH2:21][CH2:20][CH2:19]3)=[O:12])=[CH:9][N:8]=[CH:7][CH:6]=1

참가 물질

3

반응물 2

HCID 21899848Ethylacetate heptaneHCID 533121074-(2,5-Dichloro-phenoxy)-N-(1,2,3,4-tetrahydro-quinolin-8-yl)-nicotinamide

생성물 1

HCID 533121094-(2,5-Dichloro-phenoxy)-N-methyl-N-(1,2,3,4-tetrahydro-quinolin-8-yl)-nicotinamide

실험 절차

The title compound was prepared in analogy to Example 12, from 4-(2,5-dichloro-phenoxy)-N-(1,2,3,4-tetrahydro-quinolin-8-yl)-nicotinamide (Example 22) and using a gradient of n-heptane:ethyl acetate (100:0 to 0:100) for the chromatographic purification. Colorless foam (42%). MS (ESI): m/z=428.092 [M+H]+.

후처리

  1. customfor the chromatographic purification

출처 및 근거

ORD 기록
ord-afe1da8dfbd34b7282264e5a6a326779
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420647B2

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