3-Chloro-2,6-difluorobenzaldehyde → HCID 178517957, 화합물

HRID 1967128노트

반응식

HRID 1967128 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Cl:11][C:12]1[C:13]([F:21])=[C:14]([C:17]([F:20])=[CH:18][CH:19]=1)[CH:15]=O.[O:22]([C:24]#[N:25])[K].Cl.N1C=CC=CC=1.[N+:33]([CH:35]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH2:38][CH2:37][CH2:36]1)#[C-:34]>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:15]([C:14]4[C:17]([F:20])=[CH:18][CH:19]=[C:12]([Cl:11])[C:13]=4[F:21])[C:34](=[N:33][CH:35]4[C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:38][CH2:37][CH2:36]4)[NH:25][C:24]3=[O:22])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

7

반응물 5

HCID 7363383-Chloro-2,6-difluorobenzaldehydeHCID 27594691,2,3,4-Tetrahydro-1-isocyanonaphthaleneHCID 10176127Pyridinium chlorideHCID 178418250HCID 178418250, 화합물HCID 178507353HCID 178507353, 화합물

생성물 1

HCID 178517957HCID 178517957, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

1H-Benzoimidazol-5-ylamine (1 mmol) and 3-Chloro-2,6-difluorobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 1-Isocyano-1,2,3,4-tetrahydro-naphthalene (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

후처리

  1. additionwas added
  2. customAfter evaporation of the solvent the residue
  3. customwas purified with chromatographic methods

출처 및 근거

ORD 기록
ord-f10f4d3cd89d4ed59e64d655e59fada0
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420684B2

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