Formic Acid → 5-Bromo-2-nitrothiophene-3-carbaldehyde

HRID 1967146

반응식

HRID 1967146 반응식
[Br:1][C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([CH:10](Cl)Cl)[CH:3]=1.C(O)=[O:14]>[Cl-].[Zn+2].[Cl-].O>[Br:1][C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([CH:10]=[O:14])[CH:3]=1

참가 물질

5

반응물 2

HCID 284Formic AcidHCID 595256075-Bromo-3-(dichloromethyl)-2-nitrothiophene

생성물 1

HCID 534029475-Bromo-2-nitrothiophene-3-carbaldehyde

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 962Water용매

실험 절차

5-Bromo-3-(dichloromethyl)-2-nitrothiophene (60.5 g, 208 mmol) and zinc chloride (113 g, 832 mmol) were stirred in refluxing formic acid (800 mL) overnight. After cooling to ambient temperature, water was added and the mixture was extracted with EtOAc (4×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange solid.

후처리

  1. extractionthe mixture was extracted with EtOAc (4×)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f68080b21a334d46956aa02fd6a2cd4c
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420695B2

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