Cesium carbonate → 2-Chloro-4-(3,3,5-trimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile

HRID 1967230노트

반응식

HRID 1967230 반응식
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[CH:3]=1.[CH3:11][C:12]1([CH3:20])[C:16](=[O:17])[CH:15]([CH3:18])[NH:14][C:13]1=[O:19].C(=O)([O-])[O-].[Cs+].[Cs+].C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Cl:10][C:4]1[CH:3]=[C:2]([N:14]2[CH:15]([CH3:18])[C:16](=[O:17])[C:12]([CH3:20])([CH3:11])[C:13]2=[O:19])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

6

반응물 4

HCID 10796Cesium carbonateHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 70104204-Bromo-2-chlorobenzonitrileHCID 552998933,3,5-Trimethylpyrrolidine-2,4-dione

생성물 1

HCID 595569602-Chloro-4-(3,3,5-trimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile

시약·촉매·용매 1

HCID 9811564Bis(dibenzylideneacetone)palladium촉매

실험 절차

Using 4-bromo-2-chlorobenzonitrile (199 mg), 3,3,5-trimethylpyrrolidine-2,4-dione (100 mg), cesium carbonate (346 mg), tris(dibenzylideneacetone)dipalladium(0) (65 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (82 mg), and in the same manner as in Reference Example 3, the title compound was obtained as a colorless solid (yield: 135 mg, 69%).

출처 및 근거

ORD 기록
ord-7e6003bc55a04ede80e9365402d93fbc
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420694B2

반응 노트

불러오는 중…