HCID 59556892, 화합물 → HCID 67105229, 화합물

반응식

[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[CH:14]([CH2:15][O:16][CH3:17])[C:13](=[O:18])[C:12]([CH3:20])([CH3:19])[C:11]2=[O:21])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C([BH-](C(CC)C)C(CC)C)(CC)C.[Li+].C1COCC1>>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[C@H:14]([CH2:15][O:16][CH3:17])[C@H:13]([OH:18])[C:12]([CH3:19])([CH3:20])[C:11]2=[O:21])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

반응물 2

HCID 59556892HCID 59556892, 화합물

HCID 131725857L-SELECTRIDE tetrahydrofuran

생성물 1

HCID 67105229HCID 67105229, 화합물

실험 절차

Using 2-chloro-4-[5-(methoxymethyl)-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl]benzonitrile (170 mg) and lithium tri(sec-butyl)borohydride-THF solution (0.83 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as colorless crystals (yield: 142 mg, 83%).

출처 및 근거

ORD 기록: ord-0bbffb9ec9274fa5a96c6c55684ee7e1
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08420694B2

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