2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene → 2-Fluoro-4-(methoxymethoxy)aniline
반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[N+:12]([O-])=O.[H][H]>[C].[Pd].C(O)C>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[NH2:12]참가 물질
5
실험 절차
10% Palladium-carbon (390 mg) as a catalyst was added to an ethanol (100 mL) solution of 2-fluoro-4-(methoxymethoxy)-1-nitrobenzene (3.86 g), and stirred overnight in a hydrogen atmosphere at room temperature. The catalyst was removed through filtration, the solvent was evaporated off under reduced pressure, and the resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient) to give the entitled compound (2.40 g, 73%) as a brown oily substance.
후처리
- customThe catalyst was removed through filtration
- customthe solvent was evaporated off under reduced pressure
- customthe resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient)
출처 및 근거
- ORD 기록
- ord-fd2e952d47e043c28f0253db39672f97
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420823B2
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