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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Trifluoroacetic acid → 2-{4-(2-({(2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl L-leucinate trifluoroacetate

HRID 1968313
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HRID 1968313 반응식
C(OC([NH:8][C@H:9]([C:14]([O:16][CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[C:31]([C:32]#[N:33])=[C:30]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[N:29]=[C:28]([S:39][CH2:40][C:41]3[N:42]=[C:43]([C:46]4[CH:51]=[CH:50][C:49]([Cl:52])=[CH:48][CH:47]=4)[S:44][CH:45]=3)[C:27]=2[C:53]#[N:54])=[CH:22][CH:21]=1)=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=O)(C)(C)C.[F:55][C:56]([F:61])([F:60])[C:57]([OH:59])=[O:58]>ClCCl>[F:55][C:56]([F:61])([F:60])[C:57]([OH:59])=[O:58].[NH2:8][C@H:9]([C:14]([O:16][CH2:17][CH2:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[C:31]([C:32]#[N:33])=[C:30]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[N:29]=[C:28]([S:39][CH2:40][C:41]3[N:42]=[C:43]([C:46]4[CH:51]=[CH:50][C:49]([Cl:52])=[CH:48][CH:47]=4)[S:44][CH:45]=3)[C:27]=2[C:53]#[N:54])=[CH:24][CH:25]=1)=[O:15])[CH2:10][CH:11]([CH3:12])[CH3:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 687646672-{4-(2-({(2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl N-(tert-butoxycarbonyl)-L-leucinate

생성물 1

HCID 866438522-{4-(2-({(2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl L-leucinate trifluoroacetate

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

1.37 g (1.74 mmol) of 2-{4-(2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl N-(tert-butoxycarbonyl)-L-leucinate were initially charged in 15 ml of dichloromethane, and 15.00 ml (194.70 mmol) of trifluoroacetic acid were added. The mixture was stirred at room temperature for 1 h. After removal of the solvent under reduced pressure, the residue was dissolved in 5.00 ml of dichloromethane and 10.00 ml of diethyl ether were added. The residue formed was filtered off with suction. Drying gave 1.09 g (76.1% of theory) of the desired target compound.

후처리

  1. customAfter removal of the solvent under reduced pressure
  2. dissolutionthe residue was dissolved in 5.00 ml of dichloromethane
  3. addition10.00 ml of diethyl ether were added
  4. customThe residue formed
  5. filtrationwas filtered off with suction
  6. customDrying
  7. customgave 1.09 g (76.1% of theory) of the desired target compound

출처 및 근거

ORD 기록
ord-3b553d1f66f24a23a7f8f6da8954f994
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08420825B2

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