N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide → 2-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

HRID 1968526노트

반응식

HRID 1968526 반응식
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[CH2:4][N:5]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[N:6]1>CO.[Pd]>[NH2:10][C:8]1[CH:7]=[N:6][N:5]([CH2:4][C:3]([N:2]([CH3:14])[CH3:1])=[O:13])[CH:9]=1

참가 물질

4

반응물 1

HCID 60729245N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide

생성물 1

HCID 282806662-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide (870 mg, 4.39 mmol) in methanol (22 ml) was evacuated/purged with nitrogen and treated with Pd on carbon (87 mg, 0.082 mmol). The resulting black suspension was evacuated/purged with a hydrogen balloon and stirred under the hydrogen overnight when the mixture was filtered through celite with methanol washes. The filtrate was concentrated to give the product.

후처리

  1. customThe resulting black suspension was evacuated/purged with a hydrogen balloon
  2. filtrationwas filtered through celite with methanol washes
  3. concentrationThe filtrate was concentrated
  4. customto give the product

출처 및 근거

ORD 기록
ord-040b4427d31d498e92aa03cda395dbae
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426408B2

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