Dimethylformamide → Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate

HRID 1968916노트

반응식

HRID 1968916 반응식
[CH2:1]([O:8][P:9]([O:19][CH2:20][CH2:21][C:22]([CH3:27])([CH3:26])[C:23](O)=[O:24])([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C=O)C.C(Cl)(=O)C([Cl:36])=O>ClCCl>[P:9]([O:19][CH2:20][CH2:21][C:22]([CH3:27])([CH3:26])[C:23]([Cl:36])=[O:24])([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 672351544-{[Bis(benzyloxy)phosphoryl]oxy}-2,2-dimethylbutanoic acid

생성물 1

HCID 86616512Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of the product from Example 11B (0.211 g, 0.538 mmol) in dichloromethane (1.35 mL) at 0° C. were added DMF (4 μL) and a solution of oxalyl chloride in dichloromethane (2M, 0.538 mL) and the mixture was stirred for 45 minutes at 0° C. The solvent was evaporated under reduced pressure and the residue was used without further purification.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was used without further purification

출처 및 근거

ORD 기록
ord-6f2b0ee761524fdeab48d2484955221f
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426388B2

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