2,3-Difluoro-4-methyl-6-nitrophenol → 6-Amino-2,3-difluoro-4-methyl-phenol

HRID 1968958노트

반응식

HRID 1968958 반응식
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([N+:10]([O-])=O)[C:3]=1[OH:13].[H][H]>C(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([NH2:10])[C:3]=1[OH:13]

참가 물질

5

반응물 2

HCID 594441602,3-Difluoro-4-methyl-6-nitrophenolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 594441706-Amino-2,3-difluoro-4-methyl-phenol수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 2,3-difluoro-4-methyl-6-nitrophenol (1.2 g, 6.35 mmol) (D44) in ethanol (120 mL) was hydrogenated using a 10% Pd/C cartridge in the H-cube™ hydrogenator at 1 mL/min and full hydrogen at 25° C. Evaporation gave 2,3-difluoro-4-methyl-6-aminophenol (1.0 g, 6.28 mmol, 99% yield) as a fawn solid.

후처리

  1. customat 25° C
  2. customEvaporation

출처 및 근거

ORD 기록
ord-ffcce64ba1a6474780945b0edde08465
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426443B2

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