Triethylamine → HCID 66669764, 화합물

HRID 1969409노트

반응식

HRID 1969409 반응식
[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][NH:4][CH2:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13].CCN(CC)CC>C1COCC1>[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][N:4]([CH2:10][CH2:11][CH2:12][OH:13])[CH2:3]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 123083-Bromo-1-propanolHCID 167382865-Azaspiro[2.4]heptan-7-ol

생성물 1

HCID 66669764HCID 66669764, 화합물수율 60.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 7-hydroxy-5-azaspiro[2.4]heptane (1.23 g, 11.0 mmol) in THF (40 mL) was added 3-bromopropanol (2.3 g, 16.65 mmol) and Et3N (2.24 g, 22.2 mmol). The reaction mixture was stirred at rt for 12 hrs and then concentrated in vacuo. The residue was purified by a silica gel column chromatography (100:50:2(v/v/v) EtOAc/CH3OH/Et3N) to afford the desired compound as orange oil (1.14 g, 60%).

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by a silica gel column chromatography (100:50:2(v/v/v) EtOAc/CH3OH/Et3N)

출처 및 근거

ORD 기록
ord-e77ef172b54e454a86a7ccce6de63125
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426585B2

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