Thionyl Chloride → 1310729-90-8
반응식
[F:1][C:2]1([F:10])[CH2:5][CH:4]([S:6]([O-])(=[O:8])=[O:7])[CH2:3]1.[K+].S(Cl)([Cl:14])=O>CN(C=O)C>[F:1][C:2]1([F:10])[CH2:5][CH:4]([S:6]([Cl:14])(=[O:8])=[O:7])[CH2:3]1참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
To a suspension of potassium 3,3-difluorocyclobutane-1-sulfonate (0.250 g, 1.189 mmol) in thionyl chloride (2.60 mL, 35.7 mmol) was added DMF (3 drops). The reaction was heated to about 60° C. for about 21 h. The solvent was removed under reduced pressure and the residue was used in the next reaction without further workup or purification to afford crude 3,3-difluorocyclobutane-1-sulfonyl chloride (0.227 g, 100%) as product. 1H NMR (400 MHz, CDCl3) δ 4.33-4.17 (m, 1H), 3.28 (dd, J=11.1, 7.6 Hz, 2H), 3.21-3.05 (m, 2H).
후처리
- customThe solvent was removed under reduced pressure
- customthe residue was used in the next reaction without further workup or purification
출처 및 근거
- ORD 기록
- ord-ecf17945ccfa4220ab80ec8419e2f770
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08426411B2
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