Chlorosulfonic acid → 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid

HRID 1969935노트

반응식

HRID 1969935 반응식
[O:1]=[C:2]1[C:11]2[NH:12][CH:13]=[CH:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.C([C:17]([O-:19])=[O:18])C.[Cl:20][S:21](O)(=[O:23])=[O:22]>>[Cl:20][S:21]([C:7]1[CH:6]=[CH:5][C:4]2[NH:3][C:2](=[O:1])[C:11]3[NH:12][CH:13]=[C:14]([C:17]([OH:19])=[O:18])[C:10]=3[C:9]=2[CH:8]=1)(=[O:23])=[O:22]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 86627461HCID 86627461, 화합물

생성물 1

HCID 451210688-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid수율 60%

반응 조건

온도
0 °C

실험 절차

85 mg (0.33 mmol) of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate as prepared in the preceding synthesis 1 is added in the space of 90 minutes to 106 μL (1.65 mmol) of chlorosulfonic acid cooled to 0° C. on an ice bath. On completion of addition, the solution is stirred for 1 hour at room temperature then 3 hours at 70° C. The reaction mixture is cooled to room temperature then poured into ice water (20 mL). The mixture is stirred for 15 minutes then the solid is filtered, and taken up in methanol/toluene mixture. The solvents are evaporated to give 64 mg (60%) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a beige solid.

후처리

  1. additionOn completion of addition
  2. custom3 hours
  3. customat 70° C
  4. temperatureThe reaction mixture is cooled to room temperature
  5. stirringThe mixture is stirred for 15 minutes
  6. filtrationthe solid is filtered
  7. customThe solvents are evaporated

출처 및 근거

ORD 기록
ord-5b664e8aa71a43aeb228da7083bce479
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426437B2

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