Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1970081생성일: 2026년 10월 27일
1-Phenylthiosemicarbazide → 4-oxo-8-[2-(N'-phenyl-hydrazino)-thiazol-4-yl]-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate
https://huagongshe.com/reaction/1970081
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Phenylthiosemicarbazide | HCID 2781094 | — |
| 반응물 | 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate | HCID 86627583 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-oxo-8-[2-(N'-phenyl-hydrazino)-thiazol-4-yl]-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate | HCID 86627597 | 42.1% |
반응 단계
66 mg (1.2 mmol) of 1-phenylthiosemicarbazide is added to a suspension of 124 mg (0.33 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3.5 mL of ethanol. The mixture is stirred at 90° C. for 6 hours then the mixture is cooled to room temperature. The solvent is evaporated, then the product is purified by preparative LCMS. After drying, 62 mg (42%) of 4-oxo-8-[2-(N′-phenyl-hydrazino)-thiazol-4-yl]-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08426437B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-4d7f1c760d5b41cf994c4a0946a57eca |
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| 출처 메모 | uspto-grants-2013_04 |
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