tert-butyl N-(2-hydroxy-3-(methylamino)propyl)carbamate → [3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

HRID 1970164

반응식

HRID 1970164 반응식
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCCC)[NH:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[C:33]([O:37][C:38](=[O:46])[NH:39][CH2:40][CH:41]([OH:45])[CH2:42][NH:43][CH3:44])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38](=[O:46])[NH:39][CH2:40][CH:41]([OH:45])[CH2:42][N:43]([C:20]1[S:21][C:17](=[CH:16][C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:27]=[CH:28][C:2]([Cl:1])=[CH:3][C:4]=2[C:29]([F:30])([F:31])[F:32])[N:8]=[CH:9]3)[C:18](=[O:26])[N:19]=1)[CH3:44])([CH3:36])([CH3:34])[CH3:35]

참가 물질

3

반응물 2

HCID 58981742tert-butyl N-(2-hydroxy-3-(methylamino)propyl)carbamateHCID 866565305-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one

생성물 1

HCID 67345630[3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

실험 절차

[3-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and (2-Hydroxy-3-methylamino-propyl)-carbamic acid tert-butyl ester following General Procedure

출처 및 근거

ORD 기록
ord-cbd99b6fa89b4bf8990235543b94ca24
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426604B2

연결된 노트

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