Trifluoroacetic acid → 1-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-ol

반응식

C(O[C:6](=O)[N:7]([CH2:9][CH:10]([OH:17])[CH2:11][N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)C)(C)(C)C.C(O)(C(F)(F)F)=O>>[CH3:6][NH:7][CH2:9][CH:10]([OH:17])[CH2:11][N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 67346353tert-Butyl (2-hydroxy-3-(pyrrolidin-1-yl)propyl)(methyl)carbamate

생성물 1

HCID 225620281-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-ol

실험 절차

1-Methylamino-3-pyrrolidin-1-yl-propan-2-ol was prepared from (2-Hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-carbamic acid tert-butyl ester following General Procedure F. to generate a TFA salt.

출처 및 근거

ORD 기록: ord-5000e0cd1a6b496a9445a7f879f0ac40
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08426604B2

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