3-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester → Butyl 3-aminopyrrolidine-1-carboxylate

HRID 1970473노트

반응식

HRID 1970473 반응식
[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH:13]C(OCC2C=CC=CC=2)=O)[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 668545503-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester

생성물 1

HCID 11608053Butyl 3-aminopyrrolidine-1-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 467 mg 3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester in 10 ml ethyl acetate was stirred in the presence of 50 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5f9f7a17b08d4ee288852c9c73d4bca8
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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