3-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester → Pyrrolidin-3-yl-carbamic acid butyl ester

HRID 1970478노트

반응식

HRID 1970478 반응식
C(OC([N:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:12]1)=O)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:20]([O:19][C:17](=[O:18])[NH:16][CH:13]1[CH2:14][CH2:15][NH:11][CH2:12]1)[CH2:21][CH2:22][CH3:23]

참가 물질

4

반응물 1

HCID 668544263-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester

생성물 1

HCID 20242877Pyrrolidin-3-yl-carbamic acid butyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 467 mg 3-butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester in 10 ml ethyl acetate was stirred in the presence of 100 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bea721c1ac824d4b9b92af0dde2109ba
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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