Trifluoroacetic acid → 4-[(S)-2-Amino-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester

HRID 1970514노트

반응식

HRID 1970514 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C@@H:13]([NH:21]C(OC(C)(C)C)=O)[CH2:14][CH2:15][C:16]2[N:17]=[N:18][NH:19][N:20]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C@@H:13]([NH2:21])[CH2:14][CH2:15][C:16]2[N:17]=[N:18][NH:19][N:20]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 668552454-[(S)-2-tert-Butoxycarbonylamino-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester

생성물 1

HCID 668549534-[(S)-2-Amino-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 120 mg 4-[(S)-2-tert-butoxycarbonylamino-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester in 1.5 ml dichloromethane were added 0.4 ml TFA. After 2 h stirring at RT the solvents were removed and the residue was used without further purification. Yield: 130 mg.

후처리

  1. customwere removed
  2. customthe residue was used without further purification

출처 및 근거

ORD 기록
ord-0e3a1ab74ed94dbca8b530e93ae6f0d9
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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