Trifluoroacetic acid → Ethyl (2S)-2-methylpiperazine-1-carboxylate

HRID 1970538노트

반응식

HRID 1970538 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][C@@H:7]1[CH3:19])=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][C@@H:7]1[CH3:19])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66856048(S)-2-Methyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-ethyl ester

생성물 1

HCID 45099580Ethyl (2S)-2-methylpiperazine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2.05 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-ethyl ester in 15 ml dichloromethane was treated with 11.2 ml TFA and the resulting solution stirred for 12 h. The solvents were removed in vacuum and the crude hydrotrifluoroacetate transformed to the free amine by treatment with (Polystyrylmethyl)trimethylammonium bicarbonate in MeCN. Yield: 1.70 g.

후처리

  1. customThe solvents were removed in vacuum

출처 및 근거

ORD 기록
ord-c76b5e9e007c41d7acb3b01333ae059a
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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