Trifluoroacetic acid → (R)-benzyl 2-methylpiperazine-1-carboxylate

HRID 1970541노트

반응식

HRID 1970541 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[C@H:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 53886770(R)-4-Boc-1-Cbz-2-methyl-piperazine

생성물 1

HCID 40424346(R)-benzyl 2-methylpiperazine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 4.3 g (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.1 g.

후처리

  1. concentrationThe solution was concentrated
  2. customto give the crude hydrotrifluoroacetate

출처 및 근거

ORD 기록
ord-6a23a07fcd1442c288ef8fb2314ac3c4
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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