Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzyl 4-ethyl (2S)-2-methylpiperazine-1,4-dicarboxylate → Ethyl (3S)-3-methylpiperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzyl 4-ethyl (2S)-2-methylpiperazine-1,4-dicarboxylate | HCID 66854358 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl (3S)-3-methylpiperazine-1-carboxylate | HCID 11298228 | — |
반응 단계
A suspension of 3.5 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester and 0.4 g Pd/C (10%) in 56 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil. Yield: 1.6 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08426420B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-c8abda605ef24fc0b6aa8ee91a682fee |
| 출처 메모 | uspto-grants-2013_04 |