Trifluoroacetic acid → Propyl piperazine-1-carboxylate

HRID 1970555노트

반응식

HRID 1970555 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][CH2:18][CH3:19])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH2:18][CH3:19]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66854950Piperazine-1,4-dicarboxylic acid propyl ester tert-butyl ester

생성물 1

HCID 22393735Propyl piperazine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 7.5 g piperazine-1,4-dicarboxylic acid propyl ester tert-butyl ester in 70 ml dichloromethane were added 10 ml TFA. After stirring for 36 h the solution was concentrated and the residue codistilled with toluene twice. Yield: 9.2 g.

후처리

  1. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-a220378d76da47c3bf7c8799b5657dff
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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