Morpholine → HCID 66854150, 화합물

HRID 1970611노트

반응식

HRID 1970611 반응식
[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:46])[C@@H:15]([NH:28]C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1.N1CCOCC1>CN(C=O)C>[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:46])[C@@H:15]([NH2:28])[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 66854519(S)-4-[6-Benzyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-piperazine-1-carboxylic acid cyclobutyl ester

생성물 1

HCID 66854150HCID 66854150, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 726 mg (S)-4-[6-Benzyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-piperazine-1-carboxylic acid cyclobutyl ester in 4.0 ml DMF were added at room temperature 1.0 ml morpholine. After stirring for 2 h the reaction mixture was evaporated and the crude product thus obtained used in the next step without further purification.

후처리

  1. customwas evaporated

출처 및 근거

ORD 기록
ord-98be4198bdab49c5ad3632aff4d2b3e6
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426420B2

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