참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5,6-difluorobenzo[d]oxazol-2(3H)-one | HCID 11535637 | — |
| 반응물 | 1-(1-Bromoethyl)-3-nitrobenzene | HCID 22917838 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 5,6-difluoro-3-[1-(3-nitrophenyl)ethyl]-3H-benzoxazol-2-one | HCID 58485966 | — |
반응 단계
500 mg (2.9 mmol) of 5,6-difluoro-3H-benzoxazol-2-one, 672 mg (2.9 mmol) of (1-bromoethyl)-3-nitrobenzene and 1.58 g (11.4 mmol) of potassium carbonate are suspended in 6 ml of acetonitrile, and the mixture is stirred at 60° C. for 6 h. The mixture is subsequently diluted with 30 ml of MTBE, washed with 3×20 ml of H2O, dried over sodium sulfate and evaporated to dryness. The crude product is purified by column chromatography on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08431572B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_04 |
|---|
| ORD ID | ord-dbe0198a2b494c43ad3adb416cd78886 |
|---|
| 출처 메모 | uspto-grants-2013_04 |
|---|
