1,4-Dioxane hydrochloride → 1-Cyclopropyl-2,2-difluoroethanaminium chloride

To a solution of N-(1-cyclopropyl-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide (2.8 g, 12.4 mol) in MeOH (150 mL) was added dropwise 4 M HCl/dioxane (18.6 mL, 74.4 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum, and the solid was washed with Et2O, and dried to afford the title compound. 1H NMR (400 MHz, CD3OD) δ 6.25 (t, 1H); 2.90-3.00 (m, 1H); 1.02-1.12 (m, 1H); 0.78-0.82 (m, 2H); 0.58-0.68 (m, 2H).

1. concentrationThe reaction mixture was concentrated under vacuum
2. washthe solid was washed with Et2O
3. customdried

ORD 기록

ord-f64cac5d7bf549688862290a23bf4f51

출처 데이터셋

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08431569B2