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Imidazole → HCID 59543150, 화합물

HRID 1970985
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HRID 1970985 반응식
[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([OH:15])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C:18]([Si:21](Cl)([CH3:23])[CH3:22])([CH3:20])[CH3:19].N1C=CN=C1.C(=O)(O)[O-].[Na+]>CN(C=O)C>[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([O:15][Si:21]([C:18]([CH3:20])([CH3:19])[CH3:17])([CH3:23])[CH3:22])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 516892Sodium BicarbonateHCID 595431264-(Benzyloxy)-2-fluorocyclohexanol

생성물 1

HCID 59543150HCID 59543150, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 4-(benzyloxy)-2-fluorocyclohexanol (3.9 g, 17.4 mmol) in DMF (50 mL) were added TBSCl (3.93 g, 26.1 mmol) and imidazole (1.78 g, 26.1 mmol). The reaction was monitored by TLC. After completion of the reaction, the mixture was treated with sodium bicarbonate solution, and extracted with EtOAc. The combined organics were dried, concentrated, and purified by flash chromatography to afford the title compound.

후처리

  1. customAfter completion of the reaction
  2. extractionextracted with EtOAc
  3. customThe combined organics were dried
  4. concentrationconcentrated
  5. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-ad3f299e74ea40848ffa7c8067a2e45c
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08431569B2

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