HCID 59543150, 화합물 → 4-{[Tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanol
반응식
C([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])[CH:11]([F:23])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[Si:16]([O:15][CH:12]1[CH2:13][CH2:14][CH:9]([OH:8])[CH2:10][CH:11]1[F:23])([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]참가 물질
4
실험 절차
To a stirred solution {[4-(benzyloxy)-2-fluorocyclohexyl]oxy}(tert-butyl)dimethylsilane (4.66 g, 13.8 mmol) in MeOH (30 mL) was added Pd(OH)2 in MeOH (20 mL). The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.
후처리
- customThe flask was evacuated
- additionfilled with hydrogen several times
- waitleft
- additionThe mixture was diluted with DCM
- filtrationfiltered through a pad of Celite
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-869aa63bad364d6daf855a00922fe010
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08431569B2
반응 노트
불러오는 중…