Sodium Azide → HCID 59543137, 화합물

HRID 1970988노트

반응식

HRID 1970988 반응식
CS(O[CH:6]1[CH2:11][CH2:10][CH:9]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[CH:8]([F:20])[CH2:7]1)(=O)=O.[N-:21]=[N+:22]=[N-:23].[Na+]>CN(C=O)C.CCOC(C)=O>[N:21]([CH:6]1[CH2:11][CH2:10][CH:9]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[CH:8]([F:20])[CH2:7]1)=[N+:22]=[N-:23]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 595431564-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexyl methanesulfonate

생성물 1

HCID 59543137HCID 59543137, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
100 °C

실험 절차

To a stirred solution of 4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexyl methanesulfonate (570 mg, 1.75 mmol) in DMF (10 mL) was added sodium azide (340 mg, 5.24 mmol). The reaction mixture was heated to 100° C. overnight, diluted with EtOAc, and washed with water. The organic layer was dried, concentrated, and purified by flash chromatography to afford the title compound.

후처리

  1. washwashed with water
  2. customThe organic layer was dried
  3. concentrationconcentrated
  4. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-8b2a9d2461814b968369fa408eeedb35
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431569B2

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