HCID 59543137, 화합물 → 4-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

HRID 1970989노트

반응식

HRID 1970989 반응식
[N:1]([CH:4]1[CH2:9][CH2:8][CH:7]([O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])[CH:6]([F:18])[CH2:5]1)=[N+]=[N-]>CO.[Pd]>[Si:11]([O:10][CH:7]1[CH2:8][CH2:9][CH:4]([NH2:1])[CH2:5][CH:6]1[F:18])([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]

참가 물질

4

반응물 1

HCID 59543137HCID 59543137, 화합물

생성물 1

HCID 595431224-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매2회

실험 절차

To a stirred solution [(4-azido-2-fluorocyclohexyl)oxy](tert-butyl)dimethylsilane (1.0 g, 3.66 mmol) in MeOH (15 mL) was added Pd/C in MeOH. The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.

후처리

  1. customThe flask was evacuated
  2. additionfilled with hydrogen several times
  3. waitleft
  4. additionThe mixture was diluted with DCM
  5. filtrationfiltered through a pad of Celite
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8bae95b7b94349f9b70c918431b8eece
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431569B2

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