Diethyl Ether → HCID 178496014, 화합물

HRID 1971140노트

반응식

HRID 1971140 반응식
[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5].C(OCC)(=O)C.[ClH:38].C(OCC)C>C(OCC)(=O)C>[ClH:38].[ClH:38].[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 178496013HCID 178496013, 화합물

생성물 1

HCID 178496014HCID 178496014, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

1.71 g of 4-[((1S,2R)-2-{[amino(methoxyimino) methyl]amino}cyclohexyl)amino]-N-(2-methoxyethyl)-6-methyl quinazolin-2-carboxamide was suspended in 20 ml of ethyl acetate, and 5 ml of a 4 N hydrogen chloride-ethyl acetate solution was added thereto, and the mixture was stirred for 15 minutes. To the reaction solution, 40 ml of diethyl ether was added, and the resulting deposited substance was collected by filtration, washed with diethyl ether and dried under reduced pressure, whereby 2.01 g of a desired compound was obtained as a white powder.

후처리

  1. filtrationwas collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-02b16f873d09457092b3354807b28779
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431586B2

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