Pyrroline → 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone

반응식

[N+:1]([CH2:3][C:4]([O:6]C)=O)#[C-:2].[NH:8]1[CH:12]=[CH:11][CH2:10][CH2:9]1>>[N+:1]([CH2:3][C:4]([N:8]1[CH2:12][CH:11]=[CH:10][CH2:9]1)=[O:6])#[C-:2]

참가 물질

반응물 2

HCID 94395Pyrroline

HCID 547815Methyl isocyanoacetate

생성물 1

HCID 575712512-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone수율 73%

반응 조건

온도: 50 °C

실험 절차

Prepared in accordance with Method B with methyl isocyanoacetate (1.00 g, 10.10 mmol) and dihydro-1H-pyrrole (1.01 mL, 15.15 mmol). The reaction mixture was stirred 5 h at 50° C. and concentrated. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed with 10% aqueous citric acid (2×25 mL), dried over MgSO4, filtered and evaporated. 2-Isocyano-1-(2H-pyrrol-1(5H)-yl) ethanone SLA 07178 was obtained (1.0 g, 73% yield) as a yellow solid.

후처리

concentrationconcentrated
dissolutionThe residue was dissolved in dichloromethane (50 mL)
washthe organic layer was washed with 10% aqueous citric acid (2×25 mL)
dry with materialdried over MgSO4
filtrationfiltered
customevaporated

출처 및 근거

ORD 기록: ord-e67c9c1cc1644cda9074d3ca43df67ec
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08431599B2

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