Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1971287생성일: 2026년 10월 26일
Potassium Hydroxide → trans-(4,5-Dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone
https://huagongshe.com/reaction/1971287
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| 반응물 | Piperidine, 1-(isocyanoacetyl)- | HCID 6455474 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | trans-(4,5-Dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone | HCID 68961100 | 99% |
반응 단계
SLA 09052B was prepared in accordance with method D using thiophene-3-carbaldehyde (0.778 mL, 5.43 mmol), KOH (0.273 mg, 4.94 mmol) in methanol (5 mL) and 2-isocyano-1-(piperidin-1-yl)ethanone SLA 07116B (0.75 g, 4.94 mmol). The solution was stirred for 2 h at 0° C. After work-up (without any further purification) and drying trans-(4,5-dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone SLA 09052B was obtained as a yellow oil (1.29 g, 99% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08431599B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-9f5cf2b18bb7438f9a1c33d28ea63345 |
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| 출처 메모 | uspto-grants-2013_04 |
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