1,2-Dichloroethane → Ethyl 2-(benzylamino)propanoate

HRID 1971348노트

반응식

HRID 1971348 반응식
Cl.[CH2:2]([NH:4][C@H:5]([C:7]([OH:9])=[O:8])[CH3:6])[CH3:3].[CH:10](=O)[C:11]1C=C[CH:14]=[CH:13][CH:12]=1.Cl[CH2:19][CH2:20]Cl>>[CH2:19]([O:8][C:7](=[O:9])[CH:5]([NH:4][CH2:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:6])[CH3:20]

참가 물질

4

반응물 3

HCID 111,2-DichloroethaneHCID 240BenzaldehydeHCID 86643083Ethyl alanine hydrochloride

생성물 1

HCID 222273Ethyl 2-(benzylamino)propanoate

실험 절차

Ethyl alanine hydrochloride (5.5 g, 36.8 mmol), benzaldehyde (7.9 mL, 77.8 mmol), TEA (10.8 mL, 77.8 mmol) and NaBH(Oac)3 (16.5 g, 77.8 mmol) are taken up in 1,2-DCE (200 mL) and stirred at rt for 4 h. The reaction is then partitioned between DCM and saturated aqueous NaHCO3. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated in vacuo. The crude residue is used without further purification. MS (ESI) m/z 208.2 (M+1).

후처리

  1. customThe reaction is then partitioned between DCM and saturated aqueous NaHCO3
  2. customThe organic layer is removed
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo
  5. customThe crude residue is used without further purification

출처 및 근거

ORD 기록
ord-91c5d55cf2bf4f90b788b3ff63317f6b
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431584B2

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