1-(4-Butylphenyl)-3-chloropropan-1-one → 5-n-Butylindan-1-one

HRID 19715노트

반응식

HRID 19715 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:15])[CH2:12][CH2:13]Cl)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>S(=O)(=O)(O)O>[CH2:1]([C:5]1[CH:10]=[C:9]2[C:8](=[CH:7][CH:6]=1)[C:11](=[O:15])[CH2:12][CH2:13]2)[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 1

HCID 216365181-(4-Butylphenyl)-3-chloropropan-1-one

생성물 1

HCID 149399645-n-Butylindan-1-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

A solution of 1-(4-n-butylphenyl)-3-chloropropan-1-one (17.88 g, 79.8 mmol) in concentrated sulphuric acid (69 ml) is heated at 90° C. for 4 hours. After cooling to ambient temperature, the reaction mixture is poured on to ice and extracted with toluene. The combined organic phases are washed with saturated NaHCO3, brine, dried (MgSO4) and evaporated to afford the title compound. NMR δH 0.85 (t J 7.3 3H), 1.28 (sextet J 7.3 2H), 1.56 (quintet J 7.3 2H), 2.6 (m 4H), 3.02 (t J 5 2H), 7.10 (d J 8.3 1H), 7.20 (s 11H), 7.60 (d J 8.3 2H)

후처리

  1. additionthe reaction mixture is poured on to ice
  2. extractionextracted with toluene
  3. washThe combined organic phases are washed with saturated NaHCO3, brine
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-18da456839034051bc86ac3c860c08c1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745462B2

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