Isopropylamine → Tert-butyl 2-(isopropylamino)ethyl(prop-2-ynyl)carbamate

HRID 1971675노트

반응식

HRID 1971675 반응식
CS(O[CH2:6][CH2:7][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:9][C:10]#[CH:11])(=O)=O.[CH:19]([NH2:22])([CH3:21])[CH3:20]>>[CH:19]([NH:22][CH2:6][CH2:7][N:8]([CH2:9][C:10]#[CH:11])[C:12](=[O:13])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:21])[CH3:20]

참가 물질

3

반응물 2

HCID 6363IsopropylamineHCID 581248922-(Tert-butoxycarbonyl(prop-2-ynyl)amino)ethyl methanesulfonate

생성물 1

HCID 58124856Tert-butyl 2-(isopropylamino)ethyl(prop-2-ynyl)carbamate

실험 절차

A solution of 900 mg of 10e in 15 ml of isopropyl amine was stirred for 3 days at RT. The reaction mixture was concentrated. The residue was treated with 10 ml of sat. NaHCO3 and extracted with ethyl acetate. After drying and concentration of the organic material 750 mg of essentially pure 10f was obtained as an oil.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionThe residue was treated with 10 ml of sat. NaHCO3
  3. extractionextracted with ethyl acetate
  4. customAfter drying

출처 및 근거

ORD 기록
ord-d5805bf584344fd1ab24103e16635913
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431564B2

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