Triethylamine → 2-(Prop-2-ynyloxy)ethyl methanesulfonate

HRID 1971688노트

반응식

HRID 1971688 반응식
[CH2:1]([O:4][CH2:5][CH2:6][OH:7])[C:2]#[CH:3].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>C(OCC)C.O>[CH3:15][S:16]([O:7][CH2:6][CH2:5][O:4][CH2:1][C:2]#[CH:3])(=[O:18])=[O:17]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 775962-Propynoxyethanol

생성물 1

HCID 866505712-(Prop-2-ynyloxy)ethyl methanesulfonate

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 1.7 g of 11b and 3 ml of triethyl amine in 20 ml of diethyl ether was treated at 0° C. with 1.5 ml of methanesulfonyl chloride. The mixture was stirred for an additional 30 min and then diluted with 35 ml of water and extracted with ethyl acetate. The combined organic layers were washed with 1M aq. K2CO3 solution and water, dried and concentrated, to provide 2.45 of 11c as a colorless oil; Rf 0.45 (heptane/ethyl acetate 1/1).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with 1M aq. K2CO3 solution and water
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1f68b330314f45c9b6cecca358262577
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431564B2

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