Morpholine → 4-(5-Fluoro-2-methoxy-benzenesulfonyl)-morpholine

HRID 1971834노트

반응식

HRID 1971834 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14](Cl)(=[O:16])=[O:15])[CH:13]=1>C(Cl)Cl>[F:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:15])=[O:16])[CH:13]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 27834095-Fluoro-2-methoxybenzene-1-sulfonyl chloride

생성물 1

HCID 8499944-(5-Fluoro-2-methoxy-benzenesulfonyl)-morpholine수율 91.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

To a mixture of morpholine (5.8 g, 66.9 mmol) and TEA (9.3 ml, 66.9 mol) in CH2Cl2 (20 ml) was added dropwise a solution of the product of example 82 (5.0 g, 22 mmol) in CH2Cl2 (10 ml) at 0° C. After stirring at room temperature for one hour, the mixture was diluted with CH2Cl2, washed with water, dried and concentrated under reduced pressure. The resulting residue was purified by column chromatography (PE/EA=10/1) to give the titled compound (5.53 g, yield 90.3%).

후처리

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was purified by column chromatography (PE/EA=10/1)

출처 및 근거

ORD 기록
ord-6f71ad169f2446b982fba24e3d5a6ee6
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431581B2

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